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Escherichia coli str. K-12 substr. MG1655 (ecol0)
Gene : carB
DDBJ      :carB         carbamoyl-phosphate synthase large subunit
Swiss-Prot:CARB_ECOLI   RecName: Full=Carbamoyl-phosphate synthase large chain;         EC=6.3.5.5;AltName: Full=Carbamoyl-phosphate synthetase ammonia chain;

Homologs  Archaea  55/68 : Bacteria  844/915 : Eukaryota  192/199 : Viruses  0/175   --->[See Alignment]
a.92.1c.24.1c.30.1c.98.2d.142.1
:1073 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   1->1073 1bxrA PDBj 0.0 100.0 %
:RPS:PDB   1->1073 1c30A PDBj 0.0 97.8 %
:RPS:SCOP  1->127 1a9xA3  c.30.1.1 * 1e-25 99.2 %
:RPS:SCOP  128->402 1a9xA5  d.142.1.2 * 2e-75 100.0 %
:RPS:SCOP  403->555 1a9xA1  a.92.1.1 * 2e-46 100.0 %
:RPS:SCOP  589->678 2iojA1  c.98.2.2 * 2e-18 21.3 %
:RPS:SCOP  677->935 1a9xA6  d.142.1.2 * 7e-65 98.4 %
:RPS:SCOP  936->1073 1a9xA2  c.24.1.1 * 2e-20 100.0 %
:HMM:SCOP  4->130 1a9xA4 c.30.1.1 * 1.4e-52 61.2 %
:HMM:SCOP  128->402 1a9xA5 d.142.1.2 * 1.4e-113 52.7 %
:HMM:SCOP  396->555 1a9xA1 a.92.1.1 * 2.9e-59 47.1 %
:HMM:SCOP  556->676 1a9xA4 c.30.1.1 * 1.1e-55 62.8 %
:HMM:SCOP  674->935 1a9xA5 d.142.1.2 * 3e-108 58.8 %
:HMM:SCOP  936->1073 1a9xA2 c.24.1.1 * 4.4e-37 46.4 %
:RPS:PFM   6->123 PF00289 * CPSase_L_chain 6e-18 43.2 %
:RPS:PFM   128->333 PF02786 * CPSase_L_D2 1e-35 42.6 %
:RPS:PFM   424->547 PF02787 * CPSase_L_D3 2e-29 48.0 %
:RPS:PFM   558->669 PF00289 * CPSase_L_chain 5e-23 58.2 %
:RPS:PFM   674->874 PF02786 * CPSase_L_D2 4e-31 39.8 %
:RPS:PFM   957->1033 PF02142 * MGS 4e-08 41.6 %
:HMM:PFM   128->334 PF02786 * CPSase_L_D2 4e-80 44.6 204/211  
:HMM:PFM   674->876 PF02786 * CPSase_L_D2 7.9e-41 28.9 201/211  
:HMM:PFM   6->123 PF00289 * CPSase_L_chain 3.2e-25 37.3 102/110  
:HMM:PFM   560->669 PF00289 * CPSase_L_chain 8.3e-24 42.7 96/110  
:HMM:PFM   425->547 PF02787 * CPSase_L_D3 4.1e-44 50.0 120/121  
:HMM:PFM   957->1041 PF02142 * MGS 5.5e-21 45.9 85/95  
:BLT:SWISS 1->1073 CARB_ECOLI 0.0 100.0 %
:PROS 164->178|PS00866|CPSASE_1
:PROS 710->724|PS00866|CPSASE_1
:PROS 297->304|PS00867|CPSASE_2
:PROS 839->846|PS00867|CPSASE_2
:REPEAT 2|5->401|557->934

SeqInfo AminoSeq See neighboring genes
Links GIB DAD PEC GenoBase Abbreviations Back to title page
GT:ID AAC73144.1 GT:GENE carB GT:PRODUCT carbamoyl-phosphate synthase large subunit GT:DATABASE GIB00009CH01 GT:ORG ecol0 GB:ACCESSION GIB00009CH01 GB:LOCATION 30817..34038 GB:FROM 30817 GB:TO 34038 GB:DIRECTION + GB:GENE carB GB:PRODUCT carbamoyl-phosphate synthase large subunit GB:FUNCTION enzyme; Pyrimidine ribonucleotide biosynthesis 1.5.1.3 metabolism; building block biosynthesis; amino acids; arginine 1.5.2.2 metabolism; building block biosynthesis; nucleotide; pyrimidine biosynthesis GB:NOTE GO_process: GO:0006526 - arginine biosynthetic process; GO_process: GO:0006221 - pyrimidine nucleotide biosynthetic process GB:PROTEIN_ID AAC73144.1 GB:DB_XREF GI:1786216 ASAP:ABE-0000121 UniProtKB/Swiss-Prot:P00968 EcoGene:EG10135 GB:GENE:GENE carB LENGTH 1073 SQ:AASEQ MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAVLPTMGGQTALNCALELERQGVLEEFGVTMIGATADAIDKAEDRRRFDVAMKKIGLETARSGIAHTMEEALAVAADVGFPCIIRPSFTMGGSGGGIAYNREEFEEICARGLDLSPTKELLIDESLIGWKEYEMEVVRDKNDNCIIVCSIENFDAMGIHTGDSITVAPAQTLTDKEYQIMRNASMAVLREIGVETGGSNVQFAVNPKNGRLIVIEMNPRVSRSSALASKATGFPIAKVAAKLAVGYTLDELMNDITGGRTPASFEPSIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRTQQESLQKALRGLEVGATGFDPKVSLDDPEALTKIRRELKDAGADRIWYIADAFRAGLSVDGVFNLTNIDRWFLVQIEELVRLEEKVAEVGITGLNADFLRQLKRKGFADARLAKLAGVREAEIRKLRDQYDLHPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSTDREKIMVLGGGPNRIGQGIEFDYCCVHASLALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRIEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQHAVERLKLKQPANATVTAIEMAVEKAKEIGYPLVVRPSYVLGGRAMEIVYDEADLRRYFQTAVSVSNDAPVLLDHFLDDAVEVDVDAICDGEMVLIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDVMRQQVQKLAFELQVRGLMNVQFAVKNNEVYLIEVNPRAARTVPFVSKATGVPLAKVAARVMAGKSLAEQGVTKEVIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGRTFAEAFAKAQLGSNSTMKKHGRALLSVREGDKERVVDLAAKLLKQGFELDATHGTAIVLGEAGINPRLVNKVHEGRPHIQDRIKNGEYTYIINTTSGRRAIEDSRVIRRSALQYKVHYDTTLNGGFATAMALNADATEKVISVQEMHAQIK GT:EXON 1|1-1073:0| SW:ID CARB_ECOLI SW:DE RecName: Full=Carbamoyl-phosphate synthase large chain; EC=6.3.5.5;AltName: Full=Carbamoyl-phosphate synthetase ammonia chain; SW:GN Name=carB; Synonyms=pyrA; OrderedLocusNames=b0033, JW0031; SW:KW 3D-structure; Amino-acid biosynthesis; Arginine biosynthesis;ATP-binding; Complete proteome; Direct protein sequencing; Ligase;Manganese; Metal-binding; Nucleotide-binding; Pyrimidine biosynthesis;Repeat. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->1073|CARB_ECOLI|0.0|100.0|1073/1073| GO:SWS:NREP 7 GO:SWS GO:0008652|"GO:cellular amino acid biosynthetic process"|Amino-acid biosynthesis| GO:SWS GO:0006526|"GO:arginine biosynthetic process"|Arginine biosynthesis| GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0006221|"GO:pyrimidine nucleotide biosynthetic process"|Pyrimidine biosynthesis| PROS 164->178|PS00866|CPSASE_1|PDOC00676| PROS 710->724|PS00866|CPSASE_1|PDOC00676| PROS 297->304|PS00867|CPSASE_2|PDOC00676| PROS 839->846|PS00867|CPSASE_2|PDOC00676| NREPEAT 1 REPEAT 2|5->401|557->934| BL:PDB:NREP 1 BL:PDB:REP 1->1073|1bxrA|0.0|100.0|1073/1073| RP:PDB:NREP 1 RP:PDB:REP 1->1073|1c30A|0.0|97.8|1058/1058| RP:PFM:NREP 6 RP:PFM:REP 6->123|PF00289|6e-18|43.2|102/102|CPSase_L_chain| RP:PFM:REP 128->333|PF02786|1e-35|42.6|202/207|CPSase_L_D2| RP:PFM:REP 424->547|PF02787|2e-29|48.0|123/123|CPSase_L_D3| RP:PFM:REP 558->669|PF00289|5e-23|58.2|98/102|CPSase_L_chain| RP:PFM:REP 674->874|PF02786|4e-31|39.8|199/207|CPSase_L_D2| RP:PFM:REP 957->1033|PF02142|4e-08|41.6|77/95|MGS| HM:PFM:NREP 6 HM:PFM:REP 128->334|PF02786|4e-80|44.6|204/211|CPSase_L_D2| HM:PFM:REP 674->876|PF02786|7.9e-41|28.9|201/211|CPSase_L_D2| HM:PFM:REP 6->123|PF00289|3.2e-25|37.3|102/110|CPSase_L_chain| HM:PFM:REP 560->669|PF00289|8.3e-24|42.7|96/110|CPSase_L_chain| HM:PFM:REP 425->547|PF02787|4.1e-44|50.0|120/121|CPSase_L_D3| HM:PFM:REP 957->1041|PF02142|5.5e-21|45.9|85/95|MGS| GO:PFM:NREP 12 GO:PFM GO:0003824|"GO:catalytic activity"|PF00289|IPR005481| GO:PFM GO:0008152|"GO:metabolic process"|PF00289|IPR005481| GO:PFM GO:0003824|"GO:catalytic activity"|PF02786|IPR005479| GO:PFM GO:0005524|"GO:ATP binding"|PF02786|IPR005479| GO:PFM GO:0008152|"GO:metabolic process"|PF02786|IPR005479| GO:PFM GO:0004086|"GO:carbamoyl-phosphate synthase activity"|PF02787|IPR005480| GO:PFM GO:0006807|"GO:nitrogen compound metabolic process"|PF02787|IPR005480| GO:PFM GO:0003824|"GO:catalytic activity"|PF00289|IPR005481| GO:PFM GO:0008152|"GO:metabolic process"|PF00289|IPR005481| GO:PFM GO:0003824|"GO:catalytic activity"|PF02786|IPR005479| GO:PFM GO:0005524|"GO:ATP binding"|PF02786|IPR005479| GO:PFM GO:0008152|"GO:metabolic process"|PF02786|IPR005479| RP:SCP:NREP 6 RP:SCP:REP 1->127|1a9xA3|1e-25|99.2|127/127|c.30.1.1| RP:SCP:REP 128->402|1a9xA5|2e-75|100.0|275/275|d.142.1.2| RP:SCP:REP 403->555|1a9xA1|2e-46|100.0|153/153|a.92.1.1| RP:SCP:REP 589->678|2iojA1|2e-18|21.3|89/120|c.98.2.2| RP:SCP:REP 677->935|1a9xA6|7e-65|98.4|244/244|d.142.1.2| RP:SCP:REP 936->1073|1a9xA2|2e-20|100.0|138/138|c.24.1.1| HM:SCP:REP 4->130|1a9xA4|1.4e-52|61.2|121/0|c.30.1.1|1/2|PreATP-grasp domain| HM:SCP:REP 128->402|1a9xA5|1.4e-113|52.7|275/0|d.142.1.2|1/2|Glutathione synthetase ATP-binding domain-like| HM:SCP:REP 396->555|1a9xA1|2.9e-59|47.1|153/153|a.92.1.1|1/1|Carbamoyl phosphate synthetase, large subunit connection domain| HM:SCP:REP 556->676|1a9xA4|1.1e-55|62.8|121/0|c.30.1.1|2/2|PreATP-grasp domain| HM:SCP:REP 674->935|1a9xA5|3e-108|58.8|262/0|d.142.1.2|2/2|Glutathione synthetase ATP-binding domain-like| HM:SCP:REP 936->1073|1a9xA2|4.4e-37|46.4|138/0|c.24.1.1|1/1|Methylglyoxal synthase-like| OP:NHOMO 2200 OP:NHOMOORG 1091 OP:PATTERN ---1-22222222232-1111112111111112233332222221212121123-1-----111--22 2121421133323221111-1111111111112111232313222122121222223321211126112121111111111214433444431211-1112113111213---------------33232333322111122221111112211122121112321122112131222121121111122114322222222322222234444322255414331222124112222222222222232222121121232323222221132213333332111122111111111111111111111111122222222122-211112221212342222222-2-12212244243321211112-11122211122222213332223432333333333333-22222222443223333443343322433333333333211111111111112221112222222--11111111111111112122322232211111111111111111111111121111121113221252132111131212112111111112221312111111111111221312122212112232111111113111111111213321111223122211211111111111111211111-111111111111221121111111111-111111111111111111111111221111111111111111121111111121111111111111111111113132123221111-12----2--211211112111243243345333333323111111111222222222223122222222222222221121111111--------1-1---------------------------1--11111132 12--124-411-2254333234342432222323322222322333443334434443333343332333533324314233333333-23333242222321646-424B453244232224374272Da6-6452322413511321262242433449B34322B31E53923111K1222141452123264333 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 1073 STR:RPRED 100.0 SQ:SECSTR ccccccccEEEEEccccccTTccTHHHHHHHHHHHHHHHTTcEEEEEccccccGGGcGGGccEEEcccccHHHHHHHHHHHcccEEEccccHHHHHHHHHHHHHTTHHHHTTcEEccccHHHHHHHHcHHHHHHHHHHTTcccccEEEEccHHHHHHHHHHHcccEEEEETTccTTTTcEEEccHHHHHHHHHHHHHHcTTccEEEEEccTTcEEEEEEEEEcTTccEEEEEEEEEcccTTccGGGccEEEccccccHHHHHHHHHHHHHHHHHHTcccEEEEEEEEEcTTTccEEEEEEEccccHHHHHHHHHHcccHHHHHHHHTTTccGGGcccGGGTTccccccccccccEEEEEEEccGGGcTTccccccccccccEEEEEEEccHHHHHHHHHHHcccccccccccccTTcTTHHHHHHHHHHcccTTHHHHHHHHHHHTccHHHHHHHHcccHHHHHHHHHHHHHHHHHHHHTGGGccHHHHHHHHHTTccHHHHHHHHTccHHHHHHHHHHTTcccEEEEccccTTcccccccEEEEEccccccccccccccEEEEEccccccTTccHHHHHHHHHHHHHHHHTTcEEEEEcccTTccTTcGGGccEEEcccccHHHHHHHHHHHcccEEEcccccHHHHHHHHHHHHTTcccccccHHHHHHHHcHHHHHHHHHHHTcccccccccccHHHHHHHHHHHcccEEccccccEEccHHHHHHHHHHccccccHHHHHcTTccEEEEEccTTcEEEEEEEEEccccEEEEEEEEEEEETTccGGGccEEEccccccHHHHHHHHHHHHHHHHHHTccEEEEEEEEEETTEEEEEEEEccccTTHHHHHHHHcccHHHHHHHHHHTccHHHHTcccccccccEEEEEEEcGGGGcTTccccccccccccEEEEEEEccHHHHHHHHHHHTTcccccccEEEEEccGGGHHHHHHHHHHHHHHTcEEEEcHHHHHHHHHTTcccEEcccTTTccccHHHHHHTTcccEEEEccccHHHHHHHHHHHHHHHHTTcEEEccHHHHHHHHHHTTccTTTccccHHHHHHccc DISOP:02AL 1072-1074| PSIPRED ccccccccEEEEEccccHHHHHHHHHHHHHHHHHHHHHHcccEEEEEcccHHHccccHHHccEEEEccccHHHHHHHHHHHcccEEEEcccccccccccccHHHHHHHHHcccccccccHHHHHHHHcHHHHHHHHHHcccccccccccccHHHHHHHHHHccccEEEEEccccccccEEEEccHHHHHHHHHHHHHHcccccEEEEEEccccEEEEEEEEEcccccEEEEcccccccccccccccEEEEEccccccHHHHHHHHHHHHHHHHHccccccEEEEEEEEEccccEEEEEEEcccccccHHHHHHHccccHHHHHHHHHcccccccccccccccccccccccccccEEcccccEEEcccccccccccccccEEEEEEEEcccHHHHHHHHHHHHHcccccccccccccccccHHHHHHHHccccccHHHHHHHHHHccccHHHHHHHHcccHHHHHHHHHHHHHHHHHHHcccccccHHHHHHHHHccccHHHHHHHHcccHHHHHHHHHHcccEEEEEEEcccccccccccccEEEEEcccccccccccccEEEEEccccccccccccHHHHHHHHHHHHHHcccEEEEEEccccccccHHHHHHHHHcccccHHHHHHHHHHHcccEEEEEcccccHHHHHHHHHHccccEEcccHHHHHHHHcHHHHHHHHHHcccccccccccccHHHHHHHHHHccccEEEEEccccccccEEEEccHHHHHHHHHHHHHHcccccEEEEEcccccEEEEEEEEEcccEEEEccccccccccccccccEEEEEccccccHHHHHHHHHHHHHHHHHcccEEccEEEEEEEccEEEEEEEEccccccHHHHHHHHcccHHHHHHHHHccccccccccccccccccEEEEEccccccccccccccccccccccccEEEEEccHHHHHHHHHHHHccccccccEEEEEEccccHHHHHHHHHHHHHcccEEEEEHHHHHHHHHcccccEEEEccccccHHHHHHHHcccEEEEEEccccccccHHHHHHHHHHHHccccEEEcHHHHHHHHHHHHHcccccEEEHHHHHHHcc //