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Escherichia coli str. K-12 substr. MG1655 (ecol0)
Gene : ftsI
DDBJ      :ftsI         transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3)
Swiss-Prot:FTSI_ECOLI   RecName: Full=Peptidoglycan synthetase ftsI;         EC=2.4.1.129;AltName: Full=Peptidoglycan glycosyltransferase 3;AltName: Full=Penicillin-binding protein 3;         Short=PBP-3;Flags: Precursor;

Homologs  Archaea  0/68 : Bacteria  870/915 : Eukaryota  5/199 : Viruses  0/175   --->[See Alignment]
d.175.1e.3.1
:588 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   51->91 3eqvA PDBj 3e-04 36.6 %
:BLT:PDB   163->565 3eqvA PDBj 1e-91 43.1 %
:RPS:PDB   41->567 3dwkB PDBj 1e-77 12.3 %
:RPS:SCOP  60->228 1rp5A3  d.175.1.1 * 6e-41 20.1 %
:RPS:SCOP  235->566 1k25A4  e.3.1.1 * 2e-76 26.2 %
:HMM:SCOP  59->235 1vqqA2 d.175.1.1 * 1e-47 35.5 %
:HMM:SCOP  235->567 1qmeA4 e.3.1.1 * 1e-90 38.2 %
:RPS:PFM   66->222 PF03717 * PBP_dimer 9e-14 34.4 %
:RPS:PFM   261->549 PF00905 * Transpeptidase 1e-34 41.6 %
:HMM:PFM   260->554 PF00905 * Transpeptidase 1e-84 35.2 287/304  
:HMM:PFM   68->220 PF03717 * PBP_dimer 2.7e-37 33.6 149/177  
:BLT:SWISS 1->588 FTSI_ECOLI 0.0 100.0 %
:TM
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD PEC GenoBase Abbreviations Back to title page
GT:ID AAC73195.1 GT:GENE ftsI GT:PRODUCT transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) GT:DATABASE GIB00009CH01 GT:ORG ecol0 GB:ACCESSION GIB00009CH01 GB:LOCATION 91413..93179 GB:FROM 91413 GB:TO 93179 GB:DIRECTION + GB:GENE ftsI GB:PRODUCT transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) GB:FUNCTION enzyme; Cell division GB:NOTE septum formation; penicillin-binding protein 3; peptidoglycan synthetase; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0009252 - peptidoglycan biosynthetic process; GO_process: GO:0042493 - response to drug GB:PROTEIN_ID AAC73195.1 GB:DB_XREF GI:1786272 ASAP:ABE-0000309 UniProtKB/Swiss-Prot:P0AD68 EcoGene:EG10341 GB:GENE:GENE ftsI LENGTH 588 SQ:AASEQ MKAAAKTQKPKRQEEHANFISWRFALLCGCILLALAFLLGRVAWLQVISPDMLVKEGDMRSLRVQQVSTSRGMITDRSGRPLAVSVPVKAIWADPKEVHDAGGISVGDRWKALANALNIPLDQLSARINANPKGRFIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDSQAAHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMANSPSYNPNNLSGTPKEAMRNRTITDVFEPGSTVKPMVVMTALQRGVVRENSVLNTIPYRINGHEIKDVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSYGIYRPLSITKVDPPVPGERVFPESIVRTVVHMMESVALPGGGGVKAAIKGYRIAIKTGTAKKVGPDGRYINKYIAYTAGVAPASQPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTMNIEPDALTTGDKNEFVINQGEGTGGRS GT:EXON 1|1-588:0| SW:ID FTSI_ECOLI SW:DE RecName: Full=Peptidoglycan synthetase ftsI; EC=2.4.1.129;AltName: Full=Peptidoglycan glycosyltransferase 3;AltName: Full=Penicillin-binding protein 3; Short=PBP-3;Flags: Precursor; SW:GN Name=ftsI; Synonyms=pbpB; OrderedLocusNames=b0084, JW0082; SW:KW Antibiotic resistance; Cell cycle; Cell division; Cell inner membrane;Cell membrane; Cell shape; Cell wall biogenesis/degradation;Complete proteome; Glycosyltransferase; Membrane;Multifunctional enzyme; Peptidoglycan synthesis; Transferase;Transmembrane. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->588|FTSI_ECOLI|0.0|100.0|588/588| GO:SWS:NREP 13 GO:SWS GO:0046677|"GO:response to antibiotic"|Antibiotic resistance| GO:SWS GO:0007049|"GO:cell cycle"|Cell cycle| GO:SWS GO:0051301|"GO:cell division"|Cell division| GO:SWS GO:0005886|"GO:plasma membrane"|Cell inner membrane| GO:SWS GO:0005886|"GO:plasma membrane"|Cell membrane| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0016757|"GO:transferase activity, transferring glycosyl groups"|Glycosyltransferase| GO:SWS GO:0016020|"GO:membrane"|Membrane| GO:SWS GO:0003824|"GO:catalytic activity"|Multifunctional enzyme| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| GO:SWS GO:0016740|"GO:transferase activity"|Transferase| GO:SWS GO:0016021|"GO:integral to membrane"|Transmembrane| TM:NTM 1 TM:REGION 25->47| SEG 24->40|fallcgcillalafllg| BL:PDB:NREP 2 BL:PDB:REP 51->91|3eqvA|3e-04|36.6|41/442| BL:PDB:REP 163->565|3eqvA|1e-91|43.1|394/442| RP:PDB:NREP 1 RP:PDB:REP 41->567|3dwkB|1e-77|12.3|503/621| RP:PFM:NREP 2 RP:PFM:REP 66->222|PF03717|9e-14|34.4|157/188|PBP_dimer| RP:PFM:REP 261->549|PF00905|1e-34|41.6|267/289|Transpeptidase| HM:PFM:NREP 2 HM:PFM:REP 260->554|PF00905|1e-84|35.2|287/304|Transpeptidase| HM:PFM:REP 68->220|PF03717|2.7e-37|33.6|149/177|PBP_dimer| GO:PFM:NREP 3 GO:PFM GO:0008658|"GO:penicillin binding"|PF03717|IPR005311| GO:PFM GO:0008658|"GO:penicillin binding"|PF00905|IPR001460| GO:PFM GO:0009273|"GO:peptidoglycan-based cell wall biogenesis"|PF00905|IPR001460| RP:SCP:NREP 2 RP:SCP:REP 60->228|1rp5A3|6e-41|20.1|169/200|d.175.1.1| RP:SCP:REP 235->566|1k25A4|2e-76|26.2|305/326|e.3.1.1| HM:SCP:REP 59->235|1vqqA2|1e-47|35.5|169/0|d.175.1.1|1/1|Penicillin binding protein dimerisation domain| HM:SCP:REP 235->567|1qmeA4|1e-90|38.2|325/0|e.3.1.1|1/1|beta-lactamase/transpeptidase-like| OP:NHOMO 2044 OP:NHOMOORG 875 OP:PATTERN -------------------------------------------------------------------- 2253311222222223311-12222211111233333333244423332222131222222232232456222222223332322222223222222--222222222221111111111111112222222222221145---24222222222222223222123334322222222222231122322545779799A95A99AA94444569AA5433431333333642222212112222121122132113312211222233222212222222222222222222222222111111111111122222222212448533333334344466366633423433234444332223665222222-322211111111111111111111111111111-111111111121222211111132112222222222222222222224222122222--------222222222222222212122222222222333333344443333444423333222322222222222222222222222221111111222222222232222222222232222222232233222222222222222222222222232442222222222222222222222222222221-2122211-11142224332222222222-22322222222222222224442322244444444444343444222222222322222222222222222222343322222222222222222222222222222222333333342333323331111111112232322222323322322222222222221222222222222222222--------------------------2222222222232 ------------------------------------------------------------------------------------------------------------1-----------------------------------------------------------------1---------11--------1---- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 546 STR:RPRED 92.9 SQ:SECSTR ########################################HTTTTcTTccccccccccHHHHHHHHTcccccccHHHHHHHHHHHHHHHHHccHHHHHHHTTcccHHHHHHHTccccTTccHHHHHHHHHTTccHHHHcTTTcHHHHHHHHHHHHHHHHHTTcccHHHHHHHTTcccGGGcccccTTTTccccccccGGGHHHHHHHHHHHTTcGGGccccHHHHTTcccEEEEcccHHHHHHHHHHHHHccccccTTEEEEEEEETTTccEEEEEccTTccTTccEEEEETTTcccTTTccEEcGGGGHHHHTHHHHHHccccTTcEEEcccccccccccccTTcccEEEHHHHHHTTcHHHHHHHHHHHHHHccTTHHHHHHHHTTcccHHHHHHHHHHccccccccccHHHHTTcTTcEEcHHHHHHHHHHHTTTcEEEccccEEEEccccEEEcccHHHHHHHHHHHHTTccTTcTTTTccccccccEEEEEEEEccTTHHHTTccTTEEEEEEEEEEcccEEEEEEEEEccEEHHHHHTHHHHHHHHHHHHHcccccccccccTTEEEETTEEEETTcccc## DISOP:02AL 1-21| PSIPRED cccccccccccccHHHHcccHHHHHHHHHHHHHHHHHHHHHHHHHHEEccHHHHHHHHccEEEEEEEcccccEEEEcccEEEEEEEEEEEEEEEHHHccccHHHHHHHHHHHHHHHHcccHHHHHHHHHHccccccEEEEccccHHHHHHHHHHccccEEEEEEcccccccccccccEEEEEEcccccHHHHHHHHHHHHcccccEEEEEEcccccccccccccccccccEEEEEccHHHHHHHHHHHHHHHHHccccEEEEEEEEccccEEEEEEEcccccccccccccccHHHHHHccccccccHHHHHHHHHHHHHccccccccEEcccccccccccEEEccccccEEHHHHHHHcccHHHHHHHHHccHHHHHHHHHHcccccccccccccccccccccccccccccHHHHHHcccccccHHHHHHHHHHHHcccEEccEEEEEEEEcccccEEccHHHHHHHHHHHHHHccccccEEEccccccEEEEEEccEEEccccccccccEEEEEEEEEEcccccEEEEEEEEccccccccccccHHHHHHHHHHHHHHHcccccccccccccEEEEEEccccccccc //