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Escherichia coli str. K-12 substr. MG1655 (ecol0)
Gene : murF
DDBJ      :murF         UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase
Swiss-Prot:MURF_ECOLI   RecName: Full=UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase;         EC=6.3.2.10;AltName: Full=UDP-MurNAc-pentapeptide synthetase;AltName: Full=D-alanyl-D-alanine-adding enzyme;

Homologs  Archaea  0/68 : Bacteria  845/915 : Eukaryota  3/199 : Viruses  0/175   --->[See Alignment]
c.59.1c.72.2c.98.1
:452 amino acids
:SECSTR
:PSIPRED
:DISOPRED
:BLT:PDB   2->447 1gg4A PDBj 0.0 98.1 %
:RPS:PDB   8->443 1e8cA PDBj 2e-68 17.5 %
:RPS:SCOP  2->98 1gg4A3  c.98.1.1 * 1e-39 100.0 %
:RPS:SCOP  99->312 1gg4A4  c.72.2.1 * 2e-48 89.8 %
:RPS:SCOP  313->447 1gg4A1  c.59.1.1 * 1e-24 97.0 %
:HMM:SCOP  1->98 1gg4A3 c.98.1.1 * 4.2e-30 46.9 %
:HMM:SCOP  99->312 1gg4A4 c.72.2.1 * 9.5e-60 39.7 %
:HMM:SCOP  313->447 1gg4A1 c.59.1.1 * 6e-41 45.9 %
:RPS:PFM   27->95 PF01225 * Mur_ligase 2e-09 50.0 %
:RPS:PFM   105->283 PF08245 * Mur_ligase_M 2e-22 39.4 %
:HMM:PFM   106->292 PF08245 * Mur_ligase_M 4e-52 39.1 184/188  
:HMM:PFM   313->394 PF02875 * Mur_ligase_C 2.6e-18 32.5 80/91  
:HMM:PFM   25->94 PF01225 * Mur_ligase 3.2e-18 37.1 70/76  
:BLT:SWISS 1->452 MURF_ECOLI 0.0 100.0 %
:SEG

SeqInfo AminoSeq See neighboring genes
Links GIB DAD PEC GenoBase Abbreviations Back to title page
GT:ID AAC73197.1 GT:GENE murF GT:PRODUCT UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase GT:DATABASE GIB00009CH01 GT:ORG ecol0 GB:ACCESSION GIB00009CH01 GB:LOCATION 94650..96008 GB:FROM 94650 GB:TO 96008 GB:DIRECTION + GB:GENE murF GB:PRODUCT UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase GB:FUNCTION enzyme; Murein sacculus, peptidoglycan 1.6.7 metabolism; macromolecules (cellular constituent) biosynthesis; peptidoglycan (murein) 1.7.34 metabolism; central intermediary metabolism; peptidoglycan (murein) 1.7.34 metabolism; central intermediary metabolism; peptidoglycan (murein) turnover, recycling 7.1 location of gene products; cytoplasm GB:NOTE GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009252 - peptidoglycan biosynthetic process; GO_process: GO:0000270 - peptidoglycan metabolic process GB:PROTEIN_ID AAC73197.1 GB:DB_XREF GI:1786274 ASAP:ABE-0000313 UniProtKB/Swiss-Prot:P11880 EcoGene:EG10622 GB:GENE:GENE murF LENGTH 452 SQ:AASEQ MISVTLSQLTDILNGELQGADITLDAVTTDTRKLTPGCLFVALKGERFDAHDFADQAKAGGAGALLVSRPLDIDLPQLIVKDTRLAFGELAAWVRQQVPARVVALTGSSGKTSVKEMTAAILSQCGNTLYTAGNLNNDIGVPMTLLRLTPEYDYAVIELGANHQGEIAWTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADNNDWLNWQSVIGSRKVWRFSPNAANSDFTATNIHVTSHGTEFTLQTPTGSVDVLLPLPGRHNIANALAAAALSMSVGATLDAIKAGLANLKAVPGRLFPIQLAENQLLLDDSYNANVGSMTAAVQVLAEMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSVGKQSHAISTASGVGEHFADKTALITRLKLLIAEQQVITILVKGSRSAAMEEVVRALQENGTC GT:EXON 1|1-452:0| SW:ID MURF_ECOLI SW:DE RecName: Full=UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; EC=6.3.2.10;AltName: Full=UDP-MurNAc-pentapeptide synthetase;AltName: Full=D-alanyl-D-alanine-adding enzyme; SW:GN Name=murF; Synonyms=mra; OrderedLocusNames=b0086, JW0084; SW:KW 3D-structure; ATP-binding; Cell cycle; Cell division; Cell shape;Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;Direct protein sequencing; Ligase; Nucleotide-binding;Peptidoglycan synthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->452|MURF_ECOLI|0.0|100.0|452/452| GO:SWS:NREP 9 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0007049|"GO:cell cycle"|Cell cycle| GO:SWS GO:0051301|"GO:cell division"|Cell division| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| SEG 178->187|aalvnnlaaa| SEG 284->292|analaaaal| BL:PDB:NREP 1 BL:PDB:REP 2->447|1gg4A|0.0|98.1|430/430| RP:PDB:NREP 1 RP:PDB:REP 8->443|1e8cA|2e-68|17.5|423/482| RP:PFM:NREP 2 RP:PFM:REP 27->95|PF01225|2e-09|50.0|68/76|Mur_ligase| RP:PFM:REP 105->283|PF08245|2e-22|39.4|175/187|Mur_ligase_M| HM:PFM:NREP 3 HM:PFM:REP 106->292|PF08245|4e-52|39.1|184/188|Mur_ligase_M| HM:PFM:REP 313->394|PF02875|2.6e-18|32.5|80/91|Mur_ligase_C| HM:PFM:REP 25->94|PF01225|3.2e-18|37.1|70/76|Mur_ligase| GO:PFM:NREP 4 GO:PFM GO:0005524|"GO:ATP binding"|PF01225|IPR000713| GO:PFM GO:0009058|"GO:biosynthetic process"|PF01225|IPR000713| GO:PFM GO:0005524|"GO:ATP binding"|PF08245|IPR013221| GO:PFM GO:0009058|"GO:biosynthetic process"|PF08245|IPR013221| RP:SCP:NREP 3 RP:SCP:REP 2->98|1gg4A3|1e-39|100.0|97/98|c.98.1.1| RP:SCP:REP 99->312|1gg4A4|2e-48|89.8|206/206|c.72.2.1| RP:SCP:REP 313->447|1gg4A1|1e-24|97.0|135/135|c.59.1.1| HM:SCP:REP 1->98|1gg4A3|4.2e-30|46.9|98/98|c.98.1.1|1/1|MurE/MurF N-terminal domain| HM:SCP:REP 99->312|1gg4A4|9.5e-60|39.7|214/214|c.72.2.1|1/1|MurD-like peptide ligases, catalytic domain| HM:SCP:REP 313->447|1gg4A1|6e-41|45.9|135/135|c.59.1.1|1/1|MurD-like peptide ligases, peptide-binding domain| OP:NHOMO 1024 OP:NHOMOORG 848 OP:PATTERN -------------------------------------------------------------------- 1212211111111111111-11--11111111121211111--221111111111111111111111111111111111111122111222211221--112211323121111111111111121111111111122222---211111111111121211111112112111111111111111111111122232312312231122122222232115233222222221111111111111113222111111111111221111111111111111111111111111111111111111111111111111111111422211111111111111211111212211212221121111222111211-211211211211111111111122212122222-111111111112211211211111211222221111111111111111112111211------1-21111111111111111111111111111111111111111111111111111111111111111111111111111111211221111113111111111111111111111111-12111111111-----------1111---1-1---1111222112222111111212222112211211-11111-1-1-111111111111111111-11111111111111111111111111111111111111111111111111111111111111111111122222111112122111111111111122111111211111111111111111121111111111112222211111112111111111111111111211111111111111111--------------------------23-2112111111 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1------2-----1------- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 446 STR:RPRED 98.7 SQ:SECSTR #ccccHHcHHHHHTTTcTTccccccccEccGGGccTTcEEEEcccccccGGGGHHHHHHTTTTTccTTcEEETTEEEEEETTHHHHHHHHHHHHTTcGGGcHHHHHHHTTccEEEETTEEEETTcccEcccccccccHHHHHHHHHHHHHTTccEEEEccccHHHHHTTTTTTccccEEEEcccccccHHHHccHHHHHHHHHHHTTTcccccEEEEETTcHHHHHHHTTcTTcEEEEccTTTccEEEEEEEEEEccccEEEEEEETTcccEEEEEcccHHHHHHHHHHHHHHHHTTccHHHHHHHGGGccccTTcEEEccTTccEEEEEEcccccHHHHHHHHHHHHHTccccEEEEccccccccTHHHHHHHHHHHccEEEEccccccTccHHHHHHHHHTTcEEccHHHHHHHHHHcccTcTTcEEEEEccTTccEEEETHHHH##### DISOP:02AL 452-453| PSIPRED cccccHHHHHHHcccEEEccccccccEEcHHHHcccccEEEEccccccccHHHHHHHHHcccEEEEEcccccccccEEEEccHHHHHHHHHHHHcccccccEEEEEcccccHHHHHHHHHHHHHccccEEEEccccccccHHHHHHHHcccccEEEEEEEcccHHHHHHHHccccccEEEEccccHHHHHHcccHHHHHHHHHHHHHccccccEEEEccccHHHHHHHHHHccccEEEEccccccccEEEEEEEEcccEEEEEEEEcccEEEEEcccccHHHHHHHHHHHHHHHHccccHHHHHHHHHHcccccccEEEEEcccEEEEEEccccccHHHHHHHHHHHHHccccEEEEEEccccccccHHHHHHHHHHHHHHccccEEEEEcccHHHHHHHccccEEEccHHHHHHHHHHHccccccEEEEEccccccHHHHHHHHHHHcccc //