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Escherichia coli str. K-12 substr. MG1655 (ecol0)
Gene : ddlB
DDBJ      :ddlB         D-alanine:D-alanine ligase
Swiss-Prot:DDLB_ECOLI   RecName: Full=D-alanine--D-alanine ligase B;         EC=6.3.2.4;AltName: Full=D-alanylalanine synthetase B;AltName: Full=D-Ala-D-Ala ligase B;

Homologs  Archaea  4/68 : Bacteria  869/915 : Eukaryota  22/199 : Viruses  0/175   --->[See Alignment]
c.30.1d.142.1
:306 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   1->306 1iovA PDBj e-174 100.0 %
:RPS:PDB   4->305 1ehiA PDBj 6e-48 27.8 %
:RPS:SCOP  1->96 1iovA1  c.30.1.2 * 4e-20 100.0 %
:RPS:SCOP  97->306 1iovA2  d.142.1.1 * 1e-54 100.0 %
:HMM:SCOP  1->96 1iowA1 c.30.1.2 * 1.1e-30 55.9 %
:HMM:SCOP  97->303 1iowA2 d.142.1.1 * 1.9e-58 37.7 %
:RPS:PFM   4->86 PF01820 * Dala_Dala_lig_N 1e-16 60.2 %
:RPS:PFM   103->303 PF07478 * Dala_Dala_lig_C 6e-51 52.0 %
:HMM:PFM   103->303 PF07478 * Dala_Dala_lig_C 9.7e-73 44.9 198/203  
:HMM:PFM   4->44 PF01820 * Dala_Dala_lig_N 9.1e-12 43.9 41/117  
:HMM:PFM   52->86 PF01820 * Dala_Dala_lig_N 1.9e-14 57.1 35/117  
:BLT:SWISS 1->306 DDLB_ECOLI e-174 100.0 %
:PROS 63->74|PS00843|DALA_DALA_LIGASE_1
:PROS 248->276|PS00844|DALA_DALA_LIGASE_2

SeqInfo AminoSeq See neighboring genes
Links GIB DAD PEC GenoBase Abbreviations Back to title page
GT:ID AAC73203.1 GT:GENE ddlB GT:PRODUCT D-alanine:D-alanine ligase GT:DATABASE GIB00009CH01 GT:ORG ecol0 GB:ACCESSION GIB00009CH01 GB:LOCATION 102233..103153 GB:FROM 102233 GB:TO 103153 GB:DIRECTION + GB:GENE ddlB GB:PRODUCT D-alanine:D-alanine ligase GB:FUNCTION enzyme; Murein sacculus, peptidoglycan GB:NOTE D-alanine-D-alanine ligase B, affects cell division; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009252 - peptidoglycan biosynthetic process GB:PROTEIN_ID AAC73203.1 GB:DB_XREF GI:1786280 ASAP:ABE-0000326 UniProtKB/Swiss-Prot:P07862 EcoGene:EG10214 GB:GENE:GENE ddlB LENGTH 306 SQ:AASEQ MTDKIAVLLGGTSAEREVSLNSGAAVLAGLREGGIDAYPVDPKEVDVTQLKSMGFQKVFIALHGRGGEDGTLQGMLELMGLPYTGSGVMASALSMDKLRSKLLWQGAGLPVAPWVALTRAEFEKGLSDKQLAEISALGLPVIVKPSREGSSVGMSKVVAENALQDALRLAFQHDEEVLIEKWLSGPEFTVAILGEEILPSIRIQPSGTFYDYEAKYLSDETQYFCPAGLEASQEANLQALVLKAWTTLGCKGWGRIDVMLDSDGQFYLLEANTSPGMTSHSLVPMAARQAGMSFSQLVVRILELAD GT:EXON 1|1-306:0| SW:ID DDLB_ECOLI SW:DE RecName: Full=D-alanine--D-alanine ligase B; EC=6.3.2.4;AltName: Full=D-alanylalanine synthetase B;AltName: Full=D-Ala-D-Ala ligase B; SW:GN Name=ddlB; Synonyms=ddl; OrderedLocusNames=b0092, JW0090; SW:KW 3D-structure; ATP-binding; Cell shape;Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;Direct protein sequencing; Ligase; Magnesium; Manganese;Metal-binding; Nucleotide-binding; Peptidoglycan synthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->306|DDLB_ECOLI|e-174|100.0|306/306| GO:SWS:NREP 8 GO:SWS GO:0005524|"GO:ATP binding"|ATP-binding| GO:SWS GO:0008360|"GO:regulation of cell shape"|Cell shape| GO:SWS GO:0007047|"GO:cellular cell wall organization"|Cell wall biogenesis/degradation| GO:SWS GO:0005737|"GO:cytoplasm"|Cytoplasm| GO:SWS GO:0016874|"GO:ligase activity"|Ligase| GO:SWS GO:0046872|"GO:metal ion binding"|Metal-binding| GO:SWS GO:0000166|"GO:nucleotide binding"|Nucleotide-binding| GO:SWS GO:0009252|"GO:peptidoglycan biosynthetic process"|Peptidoglycan synthesis| PROS 63->74|PS00843|DALA_DALA_LIGASE_1|PDOC00659| PROS 248->276|PS00844|DALA_DALA_LIGASE_2|PDOC00659| BL:PDB:NREP 1 BL:PDB:REP 1->306|1iovA|e-174|100.0|306/306| RP:PDB:NREP 1 RP:PDB:REP 4->305|1ehiA|6e-48|27.8|299/360| RP:PFM:NREP 2 RP:PFM:REP 4->86|PF01820|1e-16|60.2|83/108|Dala_Dala_lig_N| RP:PFM:REP 103->303|PF07478|6e-51|52.0|196/199|Dala_Dala_lig_C| HM:PFM:NREP 3 HM:PFM:REP 103->303|PF07478|9.7e-73|44.9|198/203|Dala_Dala_lig_C| HM:PFM:REP 4->44|PF01820|9.1e-12|43.9|41/117|Dala_Dala_lig_N| HM:PFM:REP 52->86|PF01820|1.9e-14|57.1|35/117|Dala_Dala_lig_N| GO:PFM:NREP 5 GO:PFM GO:0005618|"GO:cell wall"|PF01820|IPR011127| GO:PFM GO:0008716|"GO:D-alanine-D-alanine ligase activity"|PF01820|IPR011127| GO:PFM GO:0009252|"GO:peptidoglycan biosynthetic process"|PF01820|IPR011127| GO:PFM GO:0008716|"GO:D-alanine-D-alanine ligase activity"|PF07478|IPR011095| GO:PFM GO:0009252|"GO:peptidoglycan biosynthetic process"|PF07478|IPR011095| RP:SCP:NREP 2 RP:SCP:REP 1->96|1iovA1|4e-20|100.0|96/96|c.30.1.2| RP:SCP:REP 97->306|1iovA2|1e-54|100.0|210/210|d.142.1.1| HM:SCP:REP 1->96|1iowA1|1.1e-30|55.9|93/0|c.30.1.2|1/1|PreATP-grasp domain| HM:SCP:REP 97->303|1iowA2|1.9e-58|37.7|207/0|d.142.1.1|1/1|Glutathione synthetase ATP-binding domain-like| OP:NHOMO 1127 OP:NHOMOORG 895 OP:PATTERN ----------------------------------------------1---1-1--------------1 111-311111131111111-11111111111111111111221312112331111111112232222121211111112221211211111111112--1111111112111111111111111111111111121111111111111111111111111111111111121111111111111111111111111212222122222211111122211121111111113311111111111111111111211111111111111111111111111111111111111111211111111111111111111111111114211111111111112111221321111121122111121112221111111211111111115321112112222222222221-111112111211211123222211111111131111111111111111111111111--------111111111111111111111121111111111111111111112111111211111111111111111111111111111311111111111111113211131111111111111111222244221111111111111111111111111111111111111212111111111111111111-1212111----22112212222222222-2222222222222122222222111112221222222222212222222221121111111111111111111111111121111111111111111111111111111122221212121331222111-111111111211111111112212222222111111112211221111111111--------------------------1212213112121 ------1----------------1-11-------------------------------1111---------------------------------1------------1------------------------------------------------------1---------1--1-1------3122-31--1---2 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 306 STR:RPRED 100.0 SQ:SECSTR cccEEEEEEEcccTTHHHHHHHHHHHHHHHHHHccEEEEEEEEcTTGGGGTTccccEEEEEcccTTTcccHHHHHHHHTTcccccccHHHHHHHHcHHHHHHHHHTTTcccccEEEEcTTGGGGHHHccHHHHHHHHcccEEEEEccccTTTTEEEEccHHHHHHHHHHHTTTcccEEEEEccccccEEEEEEEEccccEEEEEEEEccccHHHHTTcTTcEEEccccccHHHHHHHHHHHHHHHHHTTccEEEEEEEEEcTTccEEEEEEEccccccTTcGGGTGGGGGTccHHHHHHHHHHHHc PSIPRED cccEEEEEEccccccHHHHHHHHHHHHHHHHHcccEEEEEcccHHHHHHHHcccccEEEEEccccccccHHHHHHHHHccccEEcccHHHHHHHccHHHHHHHHHHccccccccEEEcHHHcccccHHHHHHHHHHccccEEEEEcccccEEEEEEEccHHHHHHHHHHHHHHccEEEEEEccccEEEEEEEEcccEEEEEEEEcccEEEEcccccccccEEEEccccccHHHHHHHHHHHHHHHHHHccccEEEEEEEEcccccEEEEEEccccccccccHHHHHHHHHcccHHHHHHHHHHHcc //