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Escherichia coli str. K-12 substr. MG1655 (ecol0)
Gene : lpxC
DDBJ      :lpxC         UDP-3-O-acyl N-acetylglucosamine deacetylase
Swiss-Prot:LPXC_SHISS   RecName: Full=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase;         EC=3.5.1.-;AltName: Full=UDP-3-O-acyl-GlcNAc deacetylase;

Homologs  Archaea  0/68 : Bacteria  554/915 : Eukaryota  18/199 : Viruses  0/175   --->[See Alignment]
d.14.1
:305 amino acids
:SECSTR
:PSIPRED
:BLT:PDB   1->300 2vesC PDBj e-104 58.2 %
:RPS:PDB   14->148 2c5mB PDBj 9e-23 14.0 %
:RPS:SCOP  4->124 1p42A1  d.14.1.7 * 3e-50 33.6 %
:RPS:SCOP  129->280 1p42A2  d.14.1.7 * 4e-64 32.9 %
:HMM:SCOP  2->126 1p42A1 d.14.1.7 * 8.4e-41 60.0 %
:HMM:SCOP  134->279 2go3A2 d.14.1.7 * 5.6e-55 60.6 %
:RPS:PFM   4->280 PF03331 * LpxC e-105 68.2 %
:HMM:PFM   2->280 PF03331 * LpxC 7.7e-128 55.2 277/277  
:BLT:SWISS 1->305 LPXC_SHISS e-178 100.0 %

SeqInfo AminoSeq See neighboring genes
Links GIB DAD PEC GenoBase Abbreviations Back to title page
GT:ID AAC73207.1 GT:GENE lpxC GT:PRODUCT UDP-3-O-acyl N-acetylglucosamine deacetylase GT:DATABASE GIB00009CH01 GT:ORG ecol0 GB:ACCESSION GIB00009CH01 GB:LOCATION 106557..107474 GB:FROM 106557 GB:TO 107474 GB:DIRECTION + GB:GENE lpxC GB:PRODUCT UDP-3-O-acyl N-acetylglucosamine deacetylase GB:FUNCTION enzyme; Surface polysaccharides & antigens GB:NOTE UDP-3-O-acyl N-acetylglucosamine deacetylase; lipid A biosynthesis; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0042280 - cell surface antigen activity, host-interacting; GO_process: GO:0009245 - lipid A biosynthetic process GB:PROTEIN_ID AAC73207.1 GB:DB_XREF GI:1786285 ASAP:ABE-0000336 UniProtKB/Swiss-Prot:P0A725 EcoGene:EG10265 GB:GENE:GENE lpxC LENGTH 305 SQ:AASEQ MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA GT:EXON 1|1-305:0| SW:ID LPXC_SHISS SW:DE RecName: Full=UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; EC=3.5.1.-;AltName: Full=UDP-3-O-acyl-GlcNAc deacetylase; SW:GN Name=lpxC; OrderedLocusNames=SSON_0104; SW:KW Complete proteome; Hydrolase; Lipid A biosynthesis; Lipid synthesis. SW:EXACT T SW:FUNC + BL:SWS:NREP 1 BL:SWS:REP 1->305|LPXC_SHISS|e-178|100.0|305/305| GO:SWS:NREP 3 GO:SWS GO:0016787|"GO:hydrolase activity"|Hydrolase| GO:SWS GO:0009245|"GO:lipid A biosynthetic process"|Lipid A biosynthesis| GO:SWS GO:0008610|"GO:lipid biosynthetic process"|Lipid synthesis| BL:PDB:NREP 1 BL:PDB:REP 1->300|2vesC|e-104|58.2|299/299| RP:PDB:NREP 1 RP:PDB:REP 14->148|2c5mB|9e-23|14.0|121/235| RP:PFM:NREP 1 RP:PFM:REP 4->280|PF03331|e-105|68.2|274/276|LpxC| HM:PFM:NREP 1 HM:PFM:REP 2->280|PF03331|7.7e-128|55.2|277/277|LpxC| GO:PFM:NREP 2 GO:PFM GO:0008759|"GO:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"|PF03331|IPR004463| GO:PFM GO:0009245|"GO:lipid A biosynthetic process"|PF03331|IPR004463| RP:SCP:NREP 2 RP:SCP:REP 4->124|1p42A1|3e-50|33.6|116/120|d.14.1.7| RP:SCP:REP 129->280|1p42A2|4e-64|32.9|146/147|d.14.1.7| HM:SCP:REP 2->126|1p42A1|8.4e-41|60.0|120/120|d.14.1.7|1/1|Ribosomal protein S5 domain 2-like| HM:SCP:REP 134->279|2go3A2|5.6e-55|60.6|137/0|d.14.1.7|1/1|Ribosomal protein S5 domain 2-like| OP:NHOMO 605 OP:NHOMOORG 572 OP:PATTERN -------------------------------------------------------------------- 111--------------------------------------------------------------------------------11111111111111--111111111-111111111111111111111111111----------1111111111111111111111111111111111111-----111-----------------------------------------------------------------------------------------------------------------------------------------------------------------------1---1--------11111111111111--1111111111111111111111-1121111211111111111111111111111111111111111111111111111------------1111111111111----1-----11111122221222221111222222211111111121111111111111111111111111111---11111111111--1111112111121111111-11111111111111111111111111111111111111111111111111111111111--11111------11111111111111111-1111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111111121111111111111111111111111111211111111111111111111111111111111111111111111111----------------------------------------------111 ------------------------------------------------------------------------------------------------------------1------------------------------------------------------------------1--17111-11111-51--1111- ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- STR:NPRED 300 STR:RPRED 98.4 SQ:SECSTR ccEEEEEcccEEEccEEEEccccccTcccccEEEHHHHHHHHHccccEHHHHHTccccccccTTTHHHHHTEEHHHHHTTTTccccccccEEEEEcccccccTTcccccHHHHHHHTHHHHccGGGEEEEEEEccccccETTccccccccccEEEEEEcccccTTTTTcccEEEEEccHHHHHHHTTTcccEEEHHHHHHHHTTTccTTccGGGcEEEcccccccTTccccTTHHHHHHHHHHHHHHGGGccEEEEEEEEEcccHHHHHHHHHHHHHcGGGEEEEcccTTcccccccccc##### PSIPRED cccccccccEEEEEEEEcccccEEEEEEEEcccccEEEEEEcccccccEEEccHHHHccccccEEEccccccEEEEHHHHHHHHHHccccEEEEEEcccccccccccHHHHHHHHHHcccEEccccccEEEEcccEEEEEccEEEEEEEccccEEEEEEEccccccccccEEEEEEEcHHHHHHHHHcccHHHHHHHHHHHHHcccccccccccEEEEEccEEEcccccccccccHHHHHHHHHHHHHHHcccccEEEEEEccccHHHHHHHHHHHcccccEEEEEccccccccEEEEccccccc //